Neonatal Nurse Practitioner Practice Exam

The correct answer highlights the critical importance of administering adequate blood volume when utilizing dopamine as a continuous intravenous infusion in neonates. Dopamine has dose-dependent effects on the cardiovascular system and is often used in situations where there is concern for compromised perfusion or low cardiac output.

In neonates, maintaining adequate blood volume is essential to ensure that the therapeutic effects of dopamine can be realized. If the blood volume is insufficient, the administration of dopamine may not lead to the desired increase in cardiac output or tissue perfusion. Dopamine works by stimulating dopaminergic and beta-adrenergic receptors, which can enhance cardiac contractility and increase heart rate, but these mechanisms require an adequate volume of circulating blood to translate into effective circulation and perfusion.

While factors such as cardiac output, oxygen saturation, and dosing also play roles in overall neonatal care and the pharmacodynamics of dopamine, they are secondary to the foundational requirement of having adequate blood volume for the medication to exert its beneficial effects properly. Inadequate blood volume can lead to ineffective treatment and potentially worsen the neonate’s clinical status despite dopamine administration.